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M2 phenotypes can be replaced with M(Interleukin-4 (IL-4) + Interleukin-13 (IL-13)) or according to the stimulation by cytokines [like M(IL-4) or M(IL-10), etc.].
M2 macrophages (CD68+ CD163+) exhibit tissue remodeling and repair functions, promote wound healing , angiogenesis , and resistance to Parasites / Parasitism , and favor Tumor growth
However, the molecular pathways that govern their differentiation have remained incompletely understood.
Be…