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CD4+ Th2 cell responses and Type 2 immune responses are closely related but not identical. While CD4+ Th2 cells play a crucial role in Type 2 immune responses, the latter encompasses a broader range of cellular and molecular components.
CD4+ Th2 cell responses are crucial in allergic reactions and defense against Parasites / Parasitism. These cells produce interleukin-4 (IL-4), Interleukin-5 (IL-5), Interleukin-9 (IL-9), and Interleukin-13 (IL-13), which act against extracellular parasites, especially helminths.
CD4+ Th2 cells are central to the development of allergic reactions. They mistakenly identify harmless foreign proteins (allergens) as pathogenic, triggering specific CD4+ Th2 Cell Responses that lead to allergic reactions. Allergens with protease activity, such as those from dust mites, pollen, fungi, or cockroaches, are particularly effective in triggering CD4+ Th2 Cell Responses.
CD4+ Th2 cells interact with various other immune cells to mediate their effects. The transcription factor Transcription regulator protein BACH2 (Bach2) serves as an essential regulator in CD4+ Th2 Cell Responses
Excessive CD4+ Th2 Cell Responses can lead to allergic diseases such as: