meRfi®-GM
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Polyamine Catabolism / Polyamine Metabolism
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Contents
Polyamine metabolism is a fundamental process governing the ability of T helper cells to polarize into different functional fates. Polyamines control T helper cell differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid hypusine, and mice in which T cells are deficient for hypusine develop severe intestinal inflammatory disease.
The catechol dehydroxylation is an important reaction in the microbial polyphenol metabolism of the gut, where a hydroxyl group is replaced by hydrogen. This process affects the bioactivity and bioavailability of polyphenol metabolites and varies greatly between individuals. …
References (Sources)
- A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
- Caffeic Acid Metabolism by Gnotobiotic Rats and Their Intestinal Bacteria
- Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria
- Interindividual variability in the human metabolism of ellagic acid: Contribution of Gordonibacter to urolithin production
- Microbiome–metabolomics reveals gut microbiota associated with glycine‐conjugated metabolites and polyamine metabolism in chronic kidney disease
- Polyamine metabolism is a central determinant of helper T cell lineage fidelity
- Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell