Polyamine Catabolism / Polyamine Metabolism

Polyamine metabolism is a fundamental process governing the ability of T helper cells to polarize into different functional fates. Polyamines control T helper cell differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid hypusine, and mice in which T cells are deficient for hypusine develop severe intestinal inflammatory disease.
Puleston et al. 2021 Cell 184:

The catechol dehydroxylation is an important reaction in the microbial polyphenol metabolism of the gut, where a hydroxyl group is replaced by hydrogen. This process affects the bioactivity and bioavailability of polyphenol metabolites and varies greatly between individuals. …