meRfi®-GM
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Hypusine
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Contents
Hypusine, chemically known as Nε-(4-amino-2-hydroxybutyl)-L-lysine, is a unique amino acid derivative found exclusively in Eukaryotic initiation factor 5A (eIF-5A). This post-translational modification is essential for the function of eIF-5A and has significant biological implications.
Synthesis of Hypusine
Hypusine is synthesized through a two-step enzymatic process:
- Deoxyhypusine Synthase (DHS): This enzyme catalyzes the transfer of the butylamine moiety from Spermidine to a specific lysine residue on [Eukaryotic initiation factor 5A (eIF-5A)](brain://R3e2dYBkPE6A8euhS4h-pQ/EukaryoticInitia…
References (Sources)
- Eukaryotic initiation factor 5A activity and HIV-1 Rev function
- Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification
- Is hypusine essential for eukaryotic cell proliferation?
- What Is All of the Hype About? Hypusine Signaling as a Driver of Pulmonary Hypertension
- What’s Hypusine Got to Do with Diabetes? Well, Maybe a Lot!