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Deoxyhypusine Synthase (DHS)
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Contents
Deoxyhypusine synthase (DHS) is involved in post-translational modification called hypusination. Hypusination is essential for activating eukaryotic initiation factor 5A (eIF5A).
Deoxyhypusine Synthase (DHS) catalyzes the transfer of a 4-aminobutyl residue from spermidine to a specific lysine residue on the eIF5A precursor, generating deoxyhypusine. This reaction is NAD-dependent and represents the rate-limiting step in the hypusination process.
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see also:
[Eukaryotic initiation factor 5A (eIF-5A)](brain://R3e2dYBkPE6A8euhS4h-pQ/EukaryoticInitiationFactor…