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STING (Stimulator of interferon genes)
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Stimulator of Interferon Genes (STING) is a protein that plays a crucial role in the innate immune response. It induces the production of type I interferons and pro-inflammatory cytokines when cells are infected with intracellular pathogens such as viruses, mycobacteria, and intracellular Parasites / Parasitism.
STING is an endoplasmic reticulum (ER) membrane protein that acts as an adaptor to detect cGAMP
STING is an adaptor protein that can sense the presence o…
References (Sources)
- Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- Intratumoral STING activation with T-cell checkpoint modulation generates systemic antitumor immunity
- Modified STING-activating cyclic dinucleotide derivatives significantly enhance the anti-tumor activity of therapeutic vaccines
- STING: infection, inflammation and cancer
- The cGAS–STING pathway as a therapeutic target in inflammatory diseases
- TMEM173 Drives Lethal Coagulation in Sepsis