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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

STING (Stimulator of interferon genes)

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Stimulator of Interferon Genes (STING) is a protein that plays a crucial role in the innate immune response. It induces the production of type I interferons and pro-inflammatory cytokines when cells are infected with intracellular pathogens such as viruses, mycobacteria, and intracellular Parasites / Parasitism.

STING is an endoplasmic reticulum (ER) membrane protein that acts as an adaptor to detect cGAMP
Xie et al. 2023 Nat Aging 3: 202-212

STING is an adaptor protein that can sense the presence o…

Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice
Xie et al. 2023 Nat Aging 3: 202-212
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
Ablasser et al. 2013 Nature 498: 380-384
Intratumoral STING activation with T-cell checkpoint modulation generates systemic antitumor immunity
Ager et al. 2017 Cancer Immunol Res 5: 676-84.
Modified STING-activating cyclic dinucleotide derivatives significantly enhance the anti-tumor activity of therapeutic vaccines
Leong et al. 2013
STING: infection, inflammation and cancer
Barber 2015 Nat Rev Immunol. 15(12): 760-70
Review
The cGAS–STING pathway as a therapeutic target in inflammatory diseases
Decout et al. 2021 Nat Rev Immunol 21: 548-569
TMEM173 Drives Lethal Coagulation in Sepsis
Zhang et al. 2020e Cell Host & Microbe 27: 556-570

12/16/2025