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To improve the outcomes of patients with high grade gliomas efforts must be focused on the pre-clinical screening of drugs for activity, the ability of these agents to achieve therapeutic concentrations in non-enhancing tumors, and a willingness to introduce novel compounds in minimally pre-treated patient populations.
At present, although drugs such as Temozolomide (TMZ), cisplatin and Bevacizumab & Glioma are effective in improving the overall survival of patients with [GBM]…