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Gut microbiota & Xenobiotics biodegradation / Drug metabolism

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Contents

Gut microbiota metabolizes numerous structurally diverse drugs through reactions such as reduction, hydrolysis, deamination, phosphorolysis, and decarboxylation
Zimmermann et al. 2019 Nature 570: 462-467
Martinelli & Thiele 2024 Gut Microbes 16(1): 2387400

These modifications profoundly influence drug exposure and partially explain the significant interindividual variability in drug response
Doestzada et al. 2018 Protein Cell 9(5): 432-45

Among the gut microbiota’s newly explored roles in human biology is the ability to modify t…