meRfi®-GM
Intestinal Epithelial Barrier / Mucosal Barrier / Mucus Layer
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Contents
We describe the generation and characterization of the human colon or ileum organoid models capable of functional differentiation into mature epithelial cell types. In monolayer culture, these cells formed a robust epithelial barrier with sustained transepithelial electrical resistance (TEER). This was damaged by the inflammatory cytokines IFN-gamma and TNF-alfa
Jelinsky et al. 2023 Inflammatory Bowel Diseas…
References (Sources)
- Forming a mucus barrier along the colon
- Gastrointestinal epithelial innate immunity—regionalization and organoids as new mode
- Human scFv SIgA expressed on Lactococcus lactis as a vector for the treatment of mucosal disease
- Integrative inflammasome activity in the regulation of intestinal mucosal immune responsesReview
- Selection of probiotic strains for human applications
- The impact of perinatal immune development on mucosal homeostasis and chronic inflammation
- Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy