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PAMPs (pathogen-associated molecular patterns) can activate APC which migrate to the mesenteric lymph nodes to stimulate T and B cells
APC activate CD4 T cells to differentiate into Regulatory T Cells (Tregs) and CD4+ Th17 cells, that can migrate back to the gut or enter Bloodstream / Circulatory system](brain://i9-iM1oIpEOeGPIjY5Oqkg/SystemicCirculation) and influence immunity in different sites
[APC](brain://_zEQs_Lk-…