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Th1 polarization
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Contents
Th1 polarization refers to the differentiation of naive T helper cells into T helper 1 (Th1) cells, which play a crucial role in the immune system's response to pathogens and various diseases. This process is characterized by specific cytokine production and gene expression patterns that shape the immune response.
Key Characteristics of Th1 Polarization
- Cytokine Profile: Th1 cells primarily produce interferon-gamma (IFN-gamma) and [interleukin-2 (IL-2)](brain://2Hw6CZK100ySyokjvTpVKg…
References (Sources)
- Lactobacilli activate human DC that skew T cells toward Th1 polarization
- Local TLR4 stimulation augments in situ vaccination induced via local radiation and anti-CTLA-4 checkpoint blockade through induction of CD8 T-cell independent Th1 polarization
- Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1
- Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis
- What Is an M2 Macrophage? Historical Overview of the Macrophage Polarization Model. The Th1/Th2 and M1/M2 Paradigm, the Arginine Fork