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The BCAA degradation pathway occurs partly in BAT. A total of 195 metabolites were identified.
Bacteroides dorei and Bacteroides vulgatus / Phocaeicola vulgatus exhibited improved BAT BCAA catabolism and attenuated body weight gain
Diet-Induced Obesity (DIO) Mice gavaged with Bacteroides dorei and Bacteroides vulgatus / Phocaeicola vulgatus exhibited improved BAT BCAA catabolism and attenuated body weight gain, which were not observed in BATectomized DIO mice.
Pharmacological systemic enhancement of BCAA catabolic activity reduced plasma BCAA and BCKA levels and protected against obesity
Branched-chain amino acids (BCAA) metabolism is in part dependent on the gut microbiota.
see also:
Branched-Chain Amino Acids (BCAAs) & Gut microbiota