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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Chemokine (C-C motif) ligand 2 (CCL2)

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Contents

CCL2 is produced by

Monocytes

Macrophages

Fibroblasts

Keratinocytes
Murphy 2022 W.W. Norton & Company ISBN 978-0-393-68093-5

CCL2 acts on

C-C Chemokine Receptor Type 2 (CCR2)
Murphy 2022 W.W. Norton & Company ISBN 978-0-393-68093-5

Attracted cells are

Monocytes

Large Granular Lymphocytes / Natural killer cells (NK cells)

T cells

[Basophils](brain://LlY25q_jbUyS5…

References (Sources)

CCL2 overexpression in the brain promotes glial activation and accelerates tau pathology in a mouse model of tauopathy
Joly-Amado et al. 2020 Front. Immunol. 11: 997
Janeway’s Immunobiology 10th
Murphy et al. 2022 W.W. Norton & Company ISBN 978-0-393-68093-5
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
Kanda et al. 2006 J Clin Invest 116: 1494-1505
Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer’s disease
Man et al. 2007 Neurobiol Aging 28: 485–96

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CCL2 - Wikipedia