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Interferons (IFNs)

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Discovered in 1957, interferon (IFN) was quickly recognized to rapidly induce a vital antiviral program
Philips et al. 2022 Cell 185(21): 3857-3876

Upon Interferons (IFNs) engagement, receptor Janus tyrosine kinases (JAKs) become activated, phosphorylating transcription factors STAT1/2 and orchestrating the cell-, tissue-, and organismal-level defense that resists and eliminates pathogens and restores [homeostasis](brain://5awGpytApU2UtF7EraWpyQ/Home…