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The profile of these astrocytes is often altered under neurodegenerative conditions
Castellanii & Schwartz 2020 Trends in immunology 41: 794
Recent analyses of human brain samples reveal striking changes in microglial and astrocyte transcriptomes in response to various diseases, infections, and trauma.
During disease, infection, and after trauma, microglia and astrocytes exhibit altered gene expression profiles that are predicted to affect their function and thereby the health of neurons and other CNS ce…