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There are 11 distinct microbial strains that were correlated to disease severity. Akkermansia muciniphila ameliorated whereas Ruminococcus torques and Parabacteroides distasonis exacerbated Amyotrophic Lateral Sclerosis (ALS) symptoms in the mice. Treating sod1 gene-transgene with either the bacterium A. muciniphila or with its associated metabolite [nicotinamide](brain://VJBqqcFip0qdahI30wUavQ/Niac…