meRfi®-GM
cGAS/DncV-like nucleotidyltransferase (CD-NTase) family
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Contents
The cGAS/DncV-like nucleotidyltransferase (CD-NTase) family is a large group of signaling proteins found in both animals and bacteria. This family includes enzymes such as Cyclic GMP-AMP synthase (cGAS) and DncV, which play crucial roles in immune sensing and the synthesis of diverse nucleotide signals.
Biochemical and structural studies have shown that signaling molecules produced by bacterial cGAS/DncV-like nucleotidyltransferase (CD-NTase) family specifically bind to their cognate effectors in vitro. This binding leads to the activation of effectors through oligomerization. In bacteria such as E. coli and *[Vibrio cholerae](brain://2MkohFj6IESTCSOfZGPSo…
References (Sources)
- CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity
- cGAS and CD-NTase enzymes: structure, mechanism, and evolution
- Cyclic nucleotide-induced helical structure activates a TIR immune effector
- Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae
- Innate immunity: the bacterial connection
- Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger
- STING cyclic dinucleotide sensing originated in bacteria