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Cyclic GMP-AMP synthase (cGAS)
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Contents
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that activates the type-I interferon response. It belongs to the nucleotidyltransferase family and is involved in innate antimicrobial immunity. Cyclic GMP-AMP synthase (cGAS) catalyzes the synthesis of the second messenger, cyclic GMP-AMP (cGAMP), in response to cytosolic DNA stimulation, which activates the STING adaptor protein. This cGAMP then binds to and activates the endoplasmic reticulum, initiating an [immune response](brain://5QFzqPH_7kiBWucrMxK3ow/ImmuneR…
References (Sources)
- CBASS to cGAS-STING: the origins and mechanisms of nucleotide second messenger immune signaling
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization
- HORMA domain proteins and a Trip13-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity
- Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity
- Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger