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Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that activates the type-I interferon response. It belongs to the nucleotidyltransferase family and is involved in innate antimicrobial immunity. Cyclic GMP-AMP synthase (cGAS) catalyzes the synthesis of the second messenger, cyclic GMP-AMP (cGAMP), in response to cytosolic DNA stimulation, which activates the STING adaptor protein. This cGAMP then binds to and activates the endoplasmic reticulum, initiating an [immune response](brain://5QFzqPH_7kiBWucrMxK3ow/ImmuneR…