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Tumoral immune resistance can be reversed by inhibiting tryptophan 2,3-dioxygenase (TDO). The inhibition of TDO leads to the restoration of antitumor immune responses, suggesting a potential therapeutic strategy for overcoming immune resistance in cancer.
Tryptophan 2,3 Dioxygenase (TDO) is a key enzyme in Tryptophan metabolism, initiating the kynurenine pathway (KP). This pathway primarily moderates the production of neuroactive compounds outside the central nervous system (CNS).
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see also:
[Morbus Parkinson / Parkinson's Disease (PD) & Tryptophan 2,3-dioxy…