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Uric Acid / Urate
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Contents
Uric Acid / Urate (UA) - the end product of the metabolic breakdown of purines in humans - when its concentration reaches saturation levels, forms pro-inflammatory crystals that are deposited in joints (e.g. gout)
A significant portion of Uric Acid / Urate is excreted in the gut
Uric Acid / Urate exacerbates inflammation and endothelial dysfunction, increases activity of the renin-angiotensin-aldosterone system, 20 and is increased in patients with hypertension and heart failure
Falconi et al. 2021 …
References (Sources)
- Emerging inflammasome effector mechanismReview
- Fighting Fatty Liver Diseases with Nutritional Interventions, Probiotics, Symbiotics, and Fecal Microbiota Transplantation (FMT)
- Gut bacterial metabolism contributes to host global purine homeostasis
- Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developrnents
- Uremic toxins and cardiovascular system
- Uremic toxins: an alarming danger concerning the cardiovascular system
- Uric acid extrarenal excretion: the gut microbiome as an evident yet understated factor in gout development