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Gout is a common and treatable condition caused by the accumulation of monosodium urate crystals in joints and other areas. Hyperuricemia is the main risk factor for gout.
Uric acid transporters in the kidney and intestine control uric acid levels in the body. The main transporters include GLUT9 (SLC2A9), URAT1 (SLC22A12), and ABCG2.
Monosodium urate crystals activate the NLRP3 inflammasome, releasing [Interleukin-1 (IL-1) beta (IL-1F2)](brain://vlvXVFK22VKp4yP-BFfTqQ…