-03T04:12:57.123Z","author":{"@type":"Person","name":"Professor Dr. Hans Lentzen","url":"https://merfi-online.com/about"},"description":"Interleukin-18 Receptor 1 (IL-18R1)\n[?id=3b455c85-cb24-5408-a6b1-9399dcc07034&linkText=Interleukin-18+Receptor+1+%28IL-18R1%29]\nis structurally very similar to IL-1R / Interleukin-1 Receptor\n[?id=0d17ecc1-b156-4c0a-97d3-bd0b50ac2c69&linkText=IL-1R+%2F+Interleukin-1+Receptor]\nDostert et al. 2013\n\nInterleukin-18 Receptor 1 (IL-18R1) form…","isAccessibleForFree":false,"hasPart":[{"@type":"WebPageElement","isAccessibleForFree":false,"cssSelector":".tree"},{"@type":"WebPageElement","isAccessibleForFree":false,"cssSelector":".notes"},{"@type":"WebPageElement","isAccessibleForFree":false,"cssSelector":".references"},{"@type":"WebPageElement","isAccessibleForFree":false,"cssSelector":".link"}]}21:T4cf,

Interleukin-18 Receptor 1 (IL-18R1) is structurally very similar to IL-1R / Interleukin-1 Receptor
Dostert et al. 2013

Interleukin-18 Receptor 1 (IL-18R1) forms a complex with the Interleukin 18 Receptor Accessory Protein (IL18RAP) to create a functional receptor for Interleukin-18 (IL-18). This complex is responsible for high-affinity IL-18 binding and signal transduction.
Ma et al. 2021 Cells 10(5): 964

Interleukin-18 Receptor 1 (IL-18R1) plays a critical role in mediating inflammatory responses and has emerged as a potential therapeutic target for a range of inflammatory and autoimmune conditions.

Interleukin-18 Receptor 1 (IL-18R1)

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