Naive T cells / Th0 cells

Naive T cells / Th0 cells (Tn) are activated and expanded upon stimulation by antigen, giving rise to effector and memory T cells that can mediate immediate and long-term protection
Chang et al. 2014 Nat. Immunol. 15: 1104-1115

The mesenteric lymph nodes (MLN) and gut-associated lymphoid tissue (GALT) are the main location for priming naïve T-cell responses
Shale et al. 2013 Immunol. Rev. 252: 164-182

Activation through Signal 2 (co-stimulation); Signal 2 Is Produced by Signal 0
Brunner et al. 2010