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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Naive T cells / Th0 cells

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Naive T cells / Th0 cells (Tn) are activated and expanded upon stimulation by antigen, giving rise to effector and memory T cells that can mediate immediate and long-term protection
Chang et al. 2014 Nat. Immunol. 15: 1104-1115

The mesenteric lymph nodes (MLN) and gut-associated lymphoid tissue (GALT) are the main location for priming naïve T-cell responses
Shale et al. 2013 Immunol. Rev. 252: 164-182

Activation through Signal 2 (co-stimulation); Signal 2 Is Produced by Signal 0
Brunner et al. 2010

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References (Sources)

CD4(+) T-cell subsets in intestinal inﬂammation
Shale et al. 2013 Immunol. Rev. 252: 164-182
Review
Immunometabolism: A target for the comprehension of immune response toward transplantation
Dominguez-Amorocho et al. 2019
Molecular regulation of effector and memory T cell differentiation
Chang et al. 2014 Nat. Immunol. 15: 1104-1115
Review
Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-b–Mediated Tumor Immune Evasion
Ibrahim et al., 2018
The ABC of clinical and experimental adjuvants—A brief overview
Brunner et al. 2010

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12/16/2025

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Naive T cells / Th0 cells

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