meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond

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Ipilimumab

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Ipilimumab targets the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) receptor, enhancing the immune response against the tumor mass.
Genova et al. 2012 Expert Opin. Biol. Ther. 12(7): 939-948
Redman et al., 2016

Ipilimumab is a fully human monoclonal antibody that blocks Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) to augment antitumor T-cell responses.
Lacouture et al., 2014

Ipilimumab Active Particularly in Pts with Small & Asymptomatic Brain Metastases
Maio et al. 2013

see also:
[Anti-CTLA-4 / CTLA-4 antibodies](brain://M1_BrScGZ0O3qgeB5-tC0…

References (Sources)

A prospective phase II trial exploring the association between TME biomarkers & clinical activity of ipilimumab in advanced melanoma
Hamid et al. 2011 Journal of Translational Medicine 9: 204
Advances in the management of melanoma: targeted therapy, immunotherapy and future directions
Dean & Lorigan, 2012
Development of lpilimumab: Contribution to a New Paradigm for Cancer lmmunotherapy
Hoos et al., 2010a
Moving towards molecular-guided treatments: erlotinib and clinical outcomes in non-small-cell lung cancer patients
Santarpia et al., 2013
Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy
Eggermont et al. 2016 NEJM 375: 1845-1855
Sargramostim plus Ipilimumab vs Ipilimumab Alone for Treatment of Metastatic Melanoma: A Randomized Clinical Trial
Hodi et al. 2014b
Update on the role of ipilimumab in melanoma and first data on new combination therapies
Maio et al. 2013
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meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond

Ipilimumab

Welcome to meRfi-GM!

Navigation

Contents

References (Sources)

AI Chat

Links

meRfi®-GM The Digital Textbook on Gut Microbiota and Beyond

Ipilimumab

Welcome to meRfi-GM!

Navigation

Contents

References (Sources)

AI Chat

Links

meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond