NACHT, LRR, and PYD domains-containing protein 12 (NLRP12)

NACHT proteins are widespread in bacteria, provide immunity against both DNA and RNA phages
Kibby et al. 2023 Cell 186: 2410-2424

Some bacterial NACHT proteins have domain architectures similar to human NLRs that are critical components of inflammasomes
Kibby et al. 2023 Cell 186: 2410-2424

Human disease-associated NLR mutations that cause stimulus-independent activation of the inflammasome also activate bacterial NACHT proteins, supporting a shared signaling mechanism
Kibby et al. 2023 Cell 186: 2410-2424

NACHT, LRR, and PYD domains-containing protein 12 (NLRP12) is a member of the Nod-like receptor (NLR) family
Sun et al. 2019c Evidence-Based Complementary and Alternative Medicine doi.org/10.1155/2019/9839474

A recent study [18] demonstrated that NLRP12 was significantly downregulated in patients with active UC compared to its expression in healthy subjects and patients with inactive UC.
Sun et al. 2019c Evidence-Based Complementary and Alternative Medicine doi.org/10.1155/2019/9839474

NLRP12-deficient mice are highly sensitive to dextran sulphate sodium (DSS)-induced colitis and exhibit exacerbated colonic inflammation [19, 20].
Sun et al. 2019c Evidence-Based Complementary and Alternative Medicine doi.org/10.1155/2019/9839474

TLR-4 overexpression can induce the upregulation of B lymphocyte-induced maturation protein-1 (Blimp-1)) - a zinc finger-containing transcriptional repressor that downregulates NLRP12 expression [22, 23].

Thus, reversing dysbiosis and promoting the expression of NLRP12 are important strategies for UC.