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Patients with Ulcerative colitis (UC) have a lower prevalence of Lactobacillus and increased oxidative stress, which correlates with the severity of inflammation
In 23 Ulcerative Colitis (UC) patients with 76 samples, rectal bleeding, and increased stool frequency correlated with an increase in Klebsiella and a decrease in Bacteroides spp.
Conversely, Ulcerative Colitis (UC) patients with lower calprotectin had less Klebsiella
Increased sulfoglycolysis and Biosynthesis & Ornithine correlated with symptomatic Ulcerative Colitis (UC)
Microbiome studies have shown low gut microbial richness and diversity in ulcerative colitis patients. UC patients who achieve long-term remission show evidence of substantial recovery of the gut microbial ecosystem in terms of diversity and composition. Recovery may just reflect adequate control of inflammatory activity, but higher bacterial diversity or the presence of A. muciniphila in fecal samples predicts flare-free outcomes.
Our study confirmed the presence of high levels of psycho-emotional distress in Ulcerative colitis (UC) patients, alongside alterations of the intestinal microbiota, and highlighted some families and genera of bacteria (Enterobacteriaceae, Streptococcus, Veillonella, Klebsiella, and Clostridiaceae) as potential markers of an altered gut-brain axis in these patients.
The dysbiosis of microbiota leads to changes in the tight junctions between intestinal epithelial cells, damage of intestinal epithelial barrier, disruption of the mucus layer, and an increase of intestinal permeability
The main components of the bacterial cell wall (lipopolysaccharide, peptidoglycan, and Lipoproteins) are recognized by TLRs
C-type lectin receptors recognize the components of the fungal cell wall (beta-glucan, Alfa-mannans, and alfa-mannose)
All these receptors induce downstream signaling and activate the NFKB signaling pathways, further induce abnormal Immune responses in the host and ultimately leading to the occurrence of Ulcerative Colitis (UC)
A study in 127 patients with ulcerative colitis revealed a decreased abundance of the critical Butyrate-producing bacteria, Roseburia hominis and Faecalibacterium prausnitzii, compared with healthy controls
An impaired Microbial SCFA Production might precede active ulcerative colitis
The gut microbiome likely plays a central role in the pathogenesis of IBD
By combining species-level profiles and strain-level profiles with bacterial growth rates, metabolic functions , antibiotic resistance, and virulence factor analyses using shotgun metagenomic sequencing of stool samples, key bacterial species that may be involved in ulcerative colitis are identified
Ulcerative colitis (UC) is characterized by increased mucosal permeability. It also involves a reduction in mucin-producing goblet cells and an impairment in barrier function.
Short-chain fatty acids (SCFAs), such as butyrate produced by beneficial bacteria, play a crucial role in maintaining epithelial integrity, modulating the immune system, and reducing inflammation. A decrease in these SCFAs can worsen ulcerative colitis (UC).
Odoribacter and Prevotella are inversely associated with Ulcerative colitis. Ruminococcus (e.g., Ruminococcus albus) is positively associated with Ulcerative colitis
Bacteroides vulgatus and Bacteroides thetaiotaomicron induced severe ulcerative disease
Increased activation and sensitivity of mature dendritic cells and significantly higher the level of TLR-2 and TLR-4 expressed by mucosal dendritic cells are observed in Ulcerative Colitis (UC) patients, which lead to abnormal activation of Signal transduction pathways such as the NFKB to promote the Inflammatory cascade
see also:
Dysbiosis & Inflammatory Bowel Disease (IBD)
NCT02093767 - Fructooligosaccharides (FOS) + Inulin-type fructans (ITF) / Inulin & Ulcerative colitis (UC)
Probiotics (living agents) & Ulcerative Colitis (UC)