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Goblet cells & Mucus
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Contents
The organization of the glycosylation machinery within the Goblet cell is depicted.
N-glycan addition in goblet cells is crucial for proper MUCIN-2 (MUC2) production because it ensures correct mucin folding, maturation, and secretion. Without N-glycans, MUCIN-2 (MUC2) cannot form the necessary dimers and oligomers, which are critical for its function as a gel-forming mucin
Sun et al. 2023 Molecules …
References (Sources)
- Chapter 8: O-glycans
- Mucin Glycans: A Target for Cancer Therapy
- N-glycosylation enzyme Mpi is essential for mucin O-glycosylation, host-microbe homeostasis, Paneth cell defense, and metabolism
- Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection
- The intestinal epithelium tuft cells: specification and function
- The role of goblet cells and mucus in intestinal homeostasis
- Vasoactive intestinal peptide regulates ileal goblet cell production in mice