Goblet cells & Mucus

The organization of the glycosylation machinery within the Goblet cell is depicted.
Luis & Hansson 2023 Cell Host & Microbe 31(7):

N-glycan addition in goblet cells is crucial for proper MUCIN-2 (MUC2) production because it ensures correct mucin folding, maturation, and secretion. Without N-glycans, MUCIN-2 (MUC2) cannot form the necessary dimers and oligomers, which are critical for its function as a gel-forming mucin
Sun et al. 2023 Molecules 28: 7033
Roy et al. 2025 Res Sq [Preprint] rs.3.rs-6222474

O-glycosylation initiation means the addition of N-acetylgalactosamine (GalNAc) to the protein backbone, followed by elongation with galactose, and N-acetylglucosamine, followed by termination by addition of sialic acid (i.e., Neu5Ac / N-Acetylneuraminic acid), and fucose
Marth 2022 in: Varki et al. 2022 (editors) Essentials of Glycobiology 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press
Luis & Hansson 2023 Cell Host & Microbe 31(7):

Neuronal and immunological factors help in the formation of new goblet cells and also trigger mucus secretion.
Schwerdtfeger & Tobet 2020 Physiol Rep 8(3): e14363
Yang et al. 2022f Cell 185(22): 4190-4205

Goblet cells secrete mucin for the mucus layer that shields the intestinal epithelial cells (IECs) from luminal bacteria
Gerbe et al. 2012 Cell Mol Life Sci. 69: 2907-2917
Pelaseyed et al. 2014 Immunol. Rev. 260: 8-20

see also:
Helminth Infections / Helminthiasis & Tuft Cells
Intestinal Mucosal Barrier / Mucus Layer & Composition
Sialic acids