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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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Spermine (SPM)

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Contents

Spermine can act as a pathogenic DNA-associated molecular pattern
Wang et al. 2023a Immunity 56: 272-28

Spermine condenses naked DNA (such as viral DNA) but not nucleosomal DNA
Wang et al. 2023a Immunity 56: 272-28

Spermine condenses DNA to optimize Cyclic GMP-AMP synthase (cGAS)-DNA binding and activation
Wang et al. 2023a Immunity 56: 272-28

Spermine, a well-known DNA condenser associated with viral DNA, markedly elevates cGAS activation
Wang et al. 2023a Immunity 56: 272-28

Spermine depletion reduces [Cyclic GMP-AMP synthase (cGAS)](brain://2v59IjBPRkq7CzUYEk8…

References (Sources)

Influence of breast milk polyamines on suckling rat immune system maturation
Pérez-Cano et al. 2010 Dev. Comp. Immunol. 234: 210-218
Polyamines and Kynurenines at the Intersection of Immune Modulation
Proietti et al. 2020 Trends in immunology 41: 1037
Review
Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma
Hasko et al. 2000 Shock 14: 144–149
Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS
Wang et al. 2023a Immunity 56: 272-28
Spermine Inhibition of Monocyte Activation and Inflammation
Zhang et al. 1999 Mol. Med 5: 595–605

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