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Spermine (SPM)
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Contents
Spermine can act as a pathogenic DNA-associated molecular pattern
Spermine condenses naked DNA (such as viral DNA) but not nucleosomal DNA
Spermine condenses DNA to optimize Cyclic GMP-AMP synthase (cGAS)-DNA binding and activation
Spermine, a well-known DNA condenser associated with viral DNA, markedly elevates cGAS activation
Spermine depletion reduces [Cyclic GMP-AMP synthase (cGAS)](brain://2v59IjBPRkq7CzUYEk8…
References (Sources)
- Influence of breast milk polyamines on suckling rat immune system maturation
- Polyamines and Kynurenines at the Intersection of Immune Modulation
- Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma
- Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS
- Spermine Inhibition of Monocyte Activation and Inflammation