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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Pouchitis

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Pouchitis likely has multiple causes. It results from fecal stasis in the ileal reservoir. In genetically susceptible patients, this leads to altered pouch microbiota (dysbiosis). It also causes colon metaplasia and triggers a mucosal immune response.
Shen 2012 Nat Rev Gastroenterol Hepatol 9(6): 323-333

Pouch inflammation reduces protective bacteria. Faecalibacterium prausnitzii decreases. Lactobacillus species decrease. Anaerobes decrease.
Reshef et al. 2015 Gastroenterology 149(3): 718-727
Dubinsky et al. 2020 Gastroenterology 158(3): 610-624
Gabbiadini et al. 2022 Nutrients 14(13): 2610

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References (Sources)

A comprehensive approach to pouch disorders
Quinn et al. 2019 Inflamm Bowel Dis 25(3): 460-471
Acute and chronic pouchitis-pathogenesis, diagnosis and treatment
Shen 2012 Nat Rev Gastroenterol Hepatol 9(6): 323-333
Review
Altered Bile Acid and Pouch Microbiota Composition in Patients With Chronic Pouchitis
Santiago et al. 2024 Inflammatory Bowel Diseases 30(7): 1062-1070
High-Dose Probiotics for the Treatment of Active Pouchitis
Gionchetti et al. 2007
Ileal pouch-anal anastomosis and pouchitis: the role of the microbiota in the pathogenesis and therapy
Gabbiadini et al. 2022 Nutrients 14(13): 2610
Review
Pouch inflammation is associated with a decrease in specific bacterial taxa
Reshef et al. 2015 Gastroenterology 149(3): 718-727
Predominantly antibioticresistant intestinal microbiome persists in patients with pouchitis who respond to antibiotic therapy
Dubinsky et al. 2020 Gastroenterology 158(3): 610-624

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Pouchitis

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