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It is localized as a luminal receptor on K cells, among others
G-Protein Coupled Receptor 119 (GPR119) is primarily linked to the alfa-subunit Gαs. This connection boosts adenylate cyclase activity and cyclic adenosine monophosphate (cAMP) production. As a result, there is an increase in the secretion of insulin and glucagon-like peptide-1 (GLP-1).
GPR119 is expressed in the brain. It is also found throughout the [gastrointestinal tract](brain://2ze-J2p2VEi_0VSpadeLHw/IntestineGastrointestinalTract…