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Faecalibacterium prausnitzii, when present in sufficient amounts, can inhibit inflammation and promote epithelial cell integrity. The former involves increased production of the immunosuppressive IL-10, while the latter involves increased Claudin-4 / CLDN4 expression.
The frequency of Faecalibacterium prausnitzii is routinely reduced in the gut microbiome of patients with [inflammatory bowel disease (IBD)](brain://UUceGF…