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Certain E. coli strains produce colibactin from their polyketide synthesis (pks) locus
Most Cyclomodulin-Producing E. coli (CPEC) strains harbor Colibactin-encoding polyketide synthase (pks) pathogenicity island (CoPEC, Colibactin-Producing Escherichia coli / E. coli pks +)
Deleting the Colibactin-encoding polyketide synthase (pks), the genotoxic island from E. coli NC101 decreased tumor multiplicity and invasion in AOM/Il10 −/− mice without altering intestinal inflammation.
[Colibactin](brain://-t6LmkikcU-YXzP-gu0…