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Colibactin as metabolite is made by gut bacteria with the polyketide synthase (pks) island. It causes genotoxicity and tumorigenesis in hosts. No FDA-approved drugs target colibactin yet.
Yang et al. 2026 Nat Microbiol 11: 53-66
It is a chemically unstable small molecule genotoxin produced by several bacteria (e.g., Colibactin-Producing Escherichia coli / E. coli pks +) in minute amounts, including members of the human gut m…