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Colibactin
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Contents
Colibactin is a chemically unstable small molecule genotoxin produced by several bacteria (e.g., Colibactin-Producing Escherichia coli / E. coli pks +) in minute amounts, including members of the human gut microbiota
Natural colibactin remains non-isolatable
Colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects have remained unknown for over a decade
Because the biosynthetic pathway of colibactin is only partially elucidated, t…
References (Sources)
- Colibactin-Producing Escherichia coli Induce the Formation of Invasive Carcinomas in a Chronic Inflammation-Associated Mouse Model
- E coli and colorectal cancer: a complex relationship that deserves a critical mindset
- Escherichia coli induces DNA double-strand breaks in eukaryotic cells
- Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population
- Structure elucidation of colibactin and its DNA cross-links
- The bacterial toxin colibactin triggers prophage induction
- The human gut bacterial genotoxin colibactin alkylates DNA