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Colibactin is a chemically unstable small molecule genotoxin produced by several bacteria (e.g., Colibactin-Producing Escherichia coli / E. coli pks +) in minute amounts, including members of the human gut microbiota
Natural colibactin remains non-isolatable
Colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects have remained unknown for over a decade
Because the biosynthetic pathway of colibactin is only partially elucidated, t…