meRfi®-GM
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Colitis / Intestinal Inflammation & Interleukin-23 (IL-23)
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Contents
Chronic inflammatory disorders such as inflammatory bowel diseases (Crohn’s disease, ulcerative colitis) are caused by lymphocytes that are inappropriately activated and destroy self-tissues. Recent data have assigned a disease-promoting role to Interleukin-23 (IL-23), a cytokine of the Interleukin-12 (IL-12) family
IL-23 Deficiency or blockade protects from human [IBD](brain://Npyo13gOo0idTQuOpA…
References (Sources)
- A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
- Characterization of FOXP3 + CD4 + Treg cells in Crohn’s disease
- IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
- IL-23/IL-17 immunity as a hallmark of Crohn’s disease.
- Increased expression of interleukin 17 in inflammatory bowel disease
- Interleukin-23 drives innate and T cell-mediated intestinal inflammation
- Regulatory lymphocytes and intestinal inflammation