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The gut microbiota plays a critically important role in Clostridioides difficile infection (CDI). A healthy microbiota is naturally resistant to colonization by Clostridioides (Clostridium) difficile. However, when dysbiosis occurs, often due to exposure to antimicrobials, it allows C. difficile spores to germinate and produce toxins. This can lead to symptoms that vary from mild diarrhea to severe colitis and even death.
Chilton et al. 2026 Nat Rev Microbiol 24: 215-2…