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Clostridioides difficile infection (CDI) & Gut microbiota
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Contents
The inflammation induced by Clostridioides (Clostridium) difficile toxins activity alters the gut microbiota, excluding members from the genus Bacteroides that are able to utilize the same essential nutrients released from collagen degradation.
By examining a single stool sample, patients at high risk of Clostridioides difficile infection (CDI) (recurrent) can be identified with an accuracy of >90% either before the start of antibiotic administration or 14 days after the end of antibiotic administration.
Lee et al. 2020e Inflammatory Bowel…
References (Sources)
- Are probiotic or synbiotic preparations effective for the management of clostridium difficile-associated or Radiation-Induced Diarrhea?Review
- Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
- Efficacy of Fecal Microbiota Transplantation for Recurrent C. Difficile Infection in IBD
- Enterotoxic Clostridia: Clostridioides difficile Infections
- Role of the Gut Microbiota in Resistance to Colonization by Clostridium difficleReview
- Shifts in the Gut Metabolome and Clostridium difficileTranscriptome throughout Colonization and Infection in a Mouse Model
- Temporal Gut Microbial Changes Predict Recurrent Clostridiodes Difficile Infection in Patients With and Without Ulcerative Colitis