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Aliases: AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3
Foxp3 / FOXP3 / Scurfin is acetylated for best binding to DNA
Abnormalities of Foxp3 / FOXP3 / Scurfin lead to progressive autoimmune processes
T cells express Foxp3 when TCR is stimulated by self-peptide / MHC complex
Expression of FOXP3 at low levels induces a limited T Reg cell phenotype but not suppressive function, which is only gained when FOXP3 is highly expressed
Foxp3-interacting factors for the Foxp3-dependent transcription are NFAT , Runx1 , RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3) , Zinc Finger Protein Eos (IKZF4)
Assembly of Foxp3, Foxp3-interacting factors, chromatin-remodeling factors is in parter under the control of TCR signaling
However, Foxp3 / FOXP3 / Scurfin also exist in human non Regulatory T Cells (Tregs). So, it is not a reliable marker of human Regulatory T Cells (Tregs)
Antibodies to Foxp3 / FOXP3 / Scurfin allowed the identification of Regulatory T Cells (Tregs)
Kapp & Bucy 2008
As a transcription factor, FOXP3 induces the expression of Regulatory T Cells (Tregs)-associated genes, including IL-2, CD25, CTLA-4, and miR-155
see also:
Regulatory T Cells (Tregs)