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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Beta-glucuronidases

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Bacteroides strongly correlates with the beta-glucuronidase level
Elmassry et al. 2021

The metabolism of a hundred medications is possibly altered by microbial beta-glucuronidase.
Elmassry et al. 2021

Even though the human microbiota is complex, scientists haven't exactly pinpointed which Beta-glucuronidases are responsible for reactivating drugs using proteomics.
Jariwala et al. 2020 ACS Chem Biol. 15:217-25

Beta-glucuronidases are broadly distributed in commensal bacteria and are present in humans, inhibitors need to be selective for bacterial beta-glucuronidases and nontoxic to both host cells and other gut microbes.

Structural studies revealed th…

References (Sources)

Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis
Shim et al. 2000 Planta Med. 66: 40-43
Distribution of beta-glucosidase and beta-glucuronidase activity and of beta-glucuronidase gene gus in human colonic bacteria
Dabek et al. 2008 FEMS Microbiol Ecol. 66: 487-95
Faecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats
Stringer et al. 2008 Cancer Biol Ther. 7: 1919-25
Fecal bacterial beta-glucuronidase: Control by diet
Reddy et al. 1974 Science 183: 416-7
Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats
Takasuna et al. 1996 Cancer Res 56: 3752-7
Predicting drug-metagenome interactions: Variation in the microbial β-glucuronidase level in the human gut metagenomes
Elmassry et al. 2021
The relative contributions of carboxylesterase and beta-glucuronidase in the formation of SN-38 in human colorectal tumours
Tobin et al. 2003 Oncol Rep. 10: 1977-9

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