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Beta-glucuronidases
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Contents
Bacteroides strongly correlates with the beta-glucuronidase level
The metabolism of a hundred medications is possibly altered by microbial beta-glucuronidase.
Even though the human microbiota is complex, scientists haven't exactly pinpointed which Beta-glucuronidases are responsible for reactivating drugs using proteomics.
Beta-glucuronidases are broadly distributed in commensal bacteria and are present in humans, inhibitors need to be selective for bacterial beta-glucuronidases and nontoxic to both host cells and other gut microbes.
Structural studies revealed th…
References (Sources)
- Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis
- Distribution of beta-glucosidase and beta-glucuronidase activity and of beta-glucuronidase gene gus in human colonic bacteria
- Faecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats
- Fecal bacterial beta-glucuronidase: Control by diet
- Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats
- Predicting drug-metagenome interactions: Variation in the microbial β-glucuronidase level in the human gut metagenomes
- The relative contributions of carboxylesterase and beta-glucuronidase in the formation of SN-38 in human colorectal tumours