meRfi®-GM
Tn (GalNAc-O-Ser/Thr)
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Contents
Tn (GalNAc-O-Ser/Thr) antigens are aberrantly glycosylated carbohydrate Tumor-associated antigens (TAA) found in ab. 80% of adenocarcinomas
Tn Antigens in Nipple Fluid: Carbohydrate Biomarkers for Breast Cancer Detection
Tn (GalNAc-O-Ser/Thr) is precursor to TF (Thomsen-Friedenreich) antigen (Gal beta1-3 GalNAc alfa1-Ser/Thr), which is generated by addition of beta-galactose by a galactosyltransferase
Interestingly, truncated O-glyco…
References (Sources)
- Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages
- Glioblastomas exploit truncated O - linked glycans for local and distant immune modulation via the macrophage galactose-type lectin
- Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant
- Mgl signaling augments TLR2mediated responses for enhanced IL-10 and TNF-α secretion
- Thomsen-Friedenreich and Tn Antigens in Nipple Fluid: Carbohydrate Biomarkers for Breast Cancer Detection
- Tumor-Associated antigens: Tn antigen, sTn antigen, and T antigen