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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Tn (GalNAc-O-Ser/Thr)

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Tn (GalNAc-O-Ser/Thr) antigens are aberrantly glycosylated carbohydrate Tumor-associated antigens (TAA) found in ab. 80% of adenocarcinomas
Kumar et al., 2005

Tn Antigens in Nipple Fluid: Carbohydrate Biomarkers for Breast Cancer Detection
Kumar et al., 2005

Tn (GalNAc-O-Ser/Thr) is precursor to TF (Thomsen-Friedenreich) antigen (Gal beta1-3 GalNAc alfa1-Ser/Thr), which is generated by addition of beta-galactose by a galactosyltransferase
MacLean et al. 1993

Interestingly, truncated O-glyco…

Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages
Allavena et al. 2010 Clin Dev Immunol 2010: 1-10
Glioblastomas exploit truncated O - linked glycans for local and distant immune modulation via the macrophage galactose-type lectin
Dusoswa et al. 2020 Proc Natl Acad Sci USA 117: 3693-703
Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant
MacLean et al. 1993
Mgl signaling augments TLR2mediated responses for enhanced IL-10 and TNF-α secretion
van Vliet et al. 2013 J Leukoc Biol 94: 315-23
Thomsen-Friedenreich and Tn Antigens in Nipple Fluid: Carbohydrate Biomarkers for Breast Cancer Detection
Kumar et al., 2005
Tumor-Associated antigens: Tn antigen, sTn antigen, and T antigen
Fu et al. 2016 HLA 88: 275–86
Review

12/16/2025