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Short-chain fatty acids (SCFAs), especially butyrate and propionate, act as histone deacetylase inhibitors (HDACIs), modifying gene expression in both cancer and immune cells. This epigenetic modulation can
inhibit cancer cell proliferation,
induce cell cycle arrest,
trigger apoptosis and autophagy,
increase reactive oxygen species (ROS) accumulation, contributing to tumor cell death.
References:
See also:
[Colorecta…