meRfi®-GM
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Butyrate / Butyric acid & Cancer / Tumors
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Contents
Significantly, Short-Chain Fatty Acids (SCFAs), especially butyrate, influence antitumor responses by:
- Regulating signaling pathways in dendritic cells involving Interleukin-12 (IL-12), Interleukin-27 (IL-27), and Interferon beta (IFN-beta).
- Impacting the combination therapy of tumors.
- Directly inhibiting tumors through HDAC inhibition.
Chen & Che…
References (Sources)
- Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
- Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases
- Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model
- Butyrate enhances the efficacy of radiotherapy via FOXO3A in colorectal cancer patient‑derived organoids
- The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype
- The Effects of Short-Chain Fatty Acids on Human Colon Cancer Cell Phenotype Are Associated with Histone Hyperacetylation
- The microbiome and its potential as a cancer preventive intervention