meRfi®-GM
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Antitumor Response
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Contents
Many genes play a crucial role in the body's defense against tumors. Here's a breakdown of their functions:
- CD8+ T Cell Activation and Costimulation: Certain genes are essential for activating CD8+ T cells, which are a type of immune cell that targets and destroys cancer cells. These genes also help in the costimulation process, which enhances the immune response. Examples include:
- h2-m2 (mhc-I) gene: This gene in mice is involved in presenting antigens to T cells.
- cd40 gene, cd70 gene, icam-1 gene: These genes contribute to the activation and interaction of immune cells.
- Ref…
References (Sources)
- Differential Requirement for CD70 and CD80/CD86 in Dendritic Cell-mediated Activation of Tumor Tolerized CD8 T Cells
- Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8alfa+ dendritic cells
- Interferon-γ is an autocrine mediator for dendritic cell maturation
- Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer
- Nuclear Localization of RelB Is Associated with Efiective Antigen-Presenting Cell Function
- Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes
- Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming