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Antitumor Response
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Many genes play a crucial role in the body's defense against tumors. Here's a breakdown of their functions:
- CD8+ T Cell Activation and Costimulation: Certain genes are essential for activating CD8+ T cells, which are a type of immune cell that targets and destroys cancer cells. These genes also help in the costimulation process, which enhances the immune response. Examples include:
- h2-m2 (mhc-I) gene: This gene in mice is involved in presenting antigens to T cells.
- cd40 gene, cd70 gene, icam-1 gene: These genes contribute to the activation a…
References (Sources)
- Contrasting frequencies of antitumor & anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen
- Differential Requirement for CD70 and CD80/CD86 in Dendritic Cell-mediated Activation of Tumor Tolerized CD8 T Cells
- Interferon-γ is an autocrine mediator for dendritic cell maturation
- Nuclear Localization of RelB Is Associated with Efiective Antigen-Presenting Cell Function
- Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes
- Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function
- Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming