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The incidence of irinotecan-induced diarrhea varies between 60-90%, by which the incidence of severe diarrhea is 20-40%.
The dose-limiting side effect of the common colon cancer chemotherapeutic Irinotecan is severe Diarrhea / Diarrhoea caused by symbiotic bacterial beta-glucuronidases that reactivate the drug in the gut
Irinotecan-induced diarrhea has been linked to an increase in the expression of colonic beta-glucuronidase, and also increases in beta-glucuronidase-encoding microorganisms.
Stringer et al. 2008 Cancer Biol Ther. 7: 1…