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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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= All genetic material of an organism

Our genome is passed down from our parents and stays stable throughout our life, with only a few nucleotide variations accumulating (1). By contrat, the genetic makeup of our microorganism complement, known as the human microbiome, is established at birth and evolves over time. It exhibits both significant temporal variability and personalization (2, 3).

References:

(1) Valles-Colomer et al. 2023 Nature 614: 125-135
(2) Stewart et al. 2018 Nature 562: 583-588
(3) Chen et al. 2021e

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References (Sources)

A structural variation reference for medical and population genetics
Collins et al. 2020
Temporal development of the gut microbiome in early childhood from the TEDDY study
Stewart et al. 2018 Nature 562: 583-588
The long-term genetic stability and individual specificity of the human gut microbiome
Chen et al. 2021e
The mutational constraint spectrum quantified from variation in 141,456 humans
Karczewski et al. 2020
The person-to-person transmission landscape of the gut and oral microbiomes
Valles-Colomer et al. 2023 Nature 614: 125-135

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