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The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation. Pro-inflammatory cytokines, which are produced during intestinal inflammation, including Interleukin-1 (IL-1) beta (IL-1F2), Tumor Necrosis Factor alfa (TNF-alfa), and [Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g)](brain://jJh19Xf…