The probiotic Lactiplantibacillus plantarum has emerged as a promising antagonist against Staphylococcus aureus through its multifaceted inhibitory mechanisms. Key mechanisms include:
- Bacteriocin-Mediated Membrane Disruption: Lactiplantibacillus plantarum produces bacteriocins that disrupt the cell membrane of Staphylococcus aureus
- Quorum Sensing Interference: It interferes with the quorum sensing of Staphylococcus aureus, disrupting communication and coordination among bacterial cells.
- Biofilm Degradation: Lactiplantibacillus plantarum contributes to the degradation of biofilms formed by Staphylococcus aureus
- Metabolic Competition: It competes with Staphylococcus aureus for nutrients, limiting its growth and survival.
In addition to these mechanisms, Lactiplantibacillus plantarum modulates local immune responses at infection sites, creating a less favorable inflammatory environment for Staphylococcus aureus.
The clinical relevance of these interactions is explored across various anatomical sites, including:
- Skin
- Vaginal Tract
- Urinary System
- Gastrointestinal Tract
In these areas, Lactiplantibacillus plantarum demonstrates both direct and adjunctive therapeutic potential against Staphylococcus aureus infections.
Bui et al. 2025 Front Microbiol 16: 1635123
see also:
Defending & Pathogens / Pathobionts / Pathogenic Bacteria
