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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Bile salts / Bile acids & Cancer

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Conjugated bile acids were more potent than unconjugated cholic acid in reducing pancreatic cancer cell survival
Shrader et al. 2021

Recent evidence also suggests that Bile salts / Bile acids promote anti-tumor immune response through activation and recruitment of tumoricidal immune cells such as natural killer T cells
Sipe et al. 2020 Immunol Rev 295: 220-239

At high concent…

Bile acids: a potential role in the pathogenesis of pharyngeal malignancy
Shellman et al. 2017 Clin Otolaryngol 42: 969-973
Deoxycholic Acid Triggers NLRP3 Inﬂammasome Activation and Aggravates DSS-Induced Colitis in Mice.
Zhao et al. 2016 Front. Immunol. 7: 536
Effect of bacterial contamination in bile on pancreatic cancer cell survival
Shrader et al. 2021
Gut microbiota-derived bile acids in intestinal immunity, inﬂammation, and tumorigenesis
Cai et al. 2022 Cell Host & Microbe 30(3): 289-300
Review
Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the vitamin D receptor
Pols et al. 2017 Plos One 12: e0176715
Pro-apoptotic role of the MEK/ERK pathway in ursodeoxycholic acid-induced apoptosis in SNU601 gastric cancer cells
Lim et al. 2012 Oncol. Rep. 28: 1429–1434
Relationship between fecal bile acids and the occurrence of colorectal neoplasia in experimental murine ulcerative colitis
Kajiura et al. 1998 Digestion 59: 69–72

5/29/2026